Senior Scientist - Bioassay Cell Based Sciences ARampD

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Job DescriptionnnNew hires in office-based roles in the US & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, subject to applicable law, employees working in roles that the Company determines require routine collaboration with external stakeholders, such as employees in customer facing commercial or research based roles, will be required to be fully vaccinated as a condition of employment.nnAttention NJ Applicants: In April 2020, our Company announced plans to consolidate our New Jersey campuses into a single New Jersey headquarters location in Rahway, NJ by 2023. Therefore, the NJ work location for this role will be temporarily based and the exact timing of the departmental move to Rahway, NJ will be communicated at a future date.nnWe are seeking a highly motivated Senior Scientist to join our Biologics Potency team within the Cell Based Sciences, Analytical Research and Development organization of our Company's Research Laboratories at Kenilworth, NJ. The qualified candidate will be responsible for developing, establishing pre-qualification and robustness, and transferring immunoassays and cell based potency assays to assess the biological activity of various biologics modalities such as antibodies, multifunctional proteins, peptide therapeutics, antibody-drug-conjugates, and/or cell- and gene-therapy agents. In our framework of scientific excellence, the senior scientist will be an active individual contributor to the design, execution, and interpretation of potency assays, as well as to the ongoing innovation by proposing, evaluating, and implementing innovative approaches in the field of potency assays. The successful candidate would have a deep understanding of underlying biological mechanisms and assay principles, with experience in key techniques, such as immunoassay platforms, stable cell line generation and/or cell-based assay development to assess the potency of drug candidates. Experience with multiple techniques and technologies, e.g. flow cytometry or lab automation, will be advantageous. The candidate will need to communicate results effectively, write technical reports, advise junior scientists, and participate in cross-functional teams. Experience of working in a GxP regulated laboratory environment for routine sample testing, documentation, and data verification will be a plus.u00a0 Experience of working on ADC, cell- or gene-therapy drug programs will be a plus.nnEducation Minimum Requirement: nA Ph.D.,nor a Masteru2019s Degree with a minimum of 5 yearsu2019 experience,nor a Bacheloru2019s Degree with a minimum of 8 yearsu2019 experiencenin cell biology, bioengineering, biological sciences, or related discipline in the biopharmaceutical industry.nnRequired Experience and Skills: nnnExperience in cell-based bioassay development for biologics modalities such as monoclonal antibodies, multi-domain proteins, antibody drug conjugates, peptide based therapies, or cell- and gene-therapy with deep understanding of underlying biological mechanisms and assay principles is highly desired.nnnExperience in applying a variety of biochemical, biological, and immunological techniques (such as cell-based assays, FACS, u00a0ELISA, homogenous FRET assays, reporter gene assays, qPCR, or ADCC/CDC, etc.) as used for cell-based assay development.nnnExperience working with BSL2 level biological agentsnnnA strong team player with excellent oral and written communication skills and ability to work independently.nnnStrong ability to deliver complex objectives under aggressive timelines in a rapidly changing environment.nnnnPreferred Experience and Skills:nnnProficiency in utilizing statistical software for design of experiments and dose-response curve analysis (e.g. PLA, JMP, DoE, or SoftMax Pro).nnnExperience with multiple techniques and technologies, e.g. flow cytometry, lab automation, or stable cell line generation, will be advantageous.nnnExperience with assay qualification, validation according to ICH guidelines.nnnWorking knowledge of regulatory and industry guidelines in the area of potency assay development.nnnPrior experience in working in and transferring assays to a regulated GxP testing facility will be valuable for the role.nnnExperience of working on ADC, cell- or gene-therapy drug programs will be a plus.nnnnWe are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we u201cfollow the scienceu201d that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.u00a0nnWho we are u2026 nWe are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.nnWhat we look for u2026 nImagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join usu2014and start making your impact today.nnNOTICE FOR INTERNAL APPLICANTSnIn accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.nnIf you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.nnCurrent Employees apply HEREnnCurrent Contingent Workers apply HEREnnUS and Puerto Rico Residents Only:nnOur company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.nFor more information about personal rights under Equal Employment Opportunity, visit:nEEOC PosternEEOC GINA Supplementu200bnOFCCP EEO SupplementnPay Transparency NondiscriminationnnWe are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one anotheru2019s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.nnSearch Firm Representatives Please Read Carefullyu00a0Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. u00a0No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.u00a0nnEmployee Status: nRegularnnRelocation:nDomesticnnVISA Sponsorship:nYesnnTravel Requirements:nnFlexible Work Arrangements:nnShift:nnValid Driving License:nnHazardous Material(s):nnNumber of Openings: n2nRequisition ID:R166430n,occupationalCategory:Senior Scientist}

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