Scientist Viral Vector Process Development

Profile

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

We are seeking an enthusiastic, self-driven individual to join the Viral Vector & Gene Editing Process Development team. Our team develops process and technology underpinning critical raw materials used in the manufacturing of engineered T cells, including viral vector. The primary focus of this Scientist is to drive process development of scalable, manufacturing-friendly upstream viral vector processes. The Scientist is expected to take ownership of key parts of the project as well as contribute to high-level strategies and technology platforms. This position will be responsible for communicating to internal and external collaborators, making sure all relevant stakeholders are informed about the data and status of development timelines.

Responsibilities:


Work in a collaborative, cross-functional team responsible for developing robust, scalable vector production and purification processes
Plan and execute experimental work to develop and optimize upstream unit operations for viral vector production
Act as subject matter expert for stirred tank reactor equipment and operation, guide best-practice implementation and training
Provide technical and scientific mentorship to junior staff
Work with MSAT and manufacturing colleagues to ensure successful transfer and scale-up of upstream processes
Represent viral vector and process development to leadership, stakeholders, and within cross-functional teams
Support tech transfer and on-going activities with external collaborators and service providers (CMOs, CROs)
Assist in the creation of next generation technologies and platforms for viral vector and gene editing
Author technical reports, patents, and peer-reviewed publications


Basic Qualifications:


B.A./B.S./M.S. with 8 years of biotechnology experience; Ph.D. in Chemical Engineering, Biochemistry, Virology, Bioengineering, Biology or related field, or equivalent experience.
Experience developing and optimizing scalable, manufacturing-friendly processes for the production of biologics
Deep understanding of mammalian cell culture; expertise in bioreactor and control software operation
Previous work interfacing with internal/external manufacturing and development organizations
Demonstrated excellence in experimental design, using DoE principles followed by independent execution and data analysis
Strong problem-solving and risk-based decision-making skills
Proven ability to work in a fast-paced, multi-product, matrixed environment
Effective communication including presentations to convey scientific concepts to research scientists, management teams, and external academic and industrial organizations
Understanding of GMP/ICH guidelines and regulations


Preferred Qualifications:


Documented experience developing GMP manufacturing processes for globally-regulated products, such as vaccines, biologics, or cell & gene therapies
Experience in the development of clinical viral vector manufacturing processes, including successful scale-up and transfer into GMP manufacturing
Prior success in managing small, high performing teams
Experience authoring regulatory documents, including IND and BLA filings
Proven track record of high-quality external presentations and peer-reviewed publications
Experience with viral titering methods, including ELISA, qPCR and cell-based assays


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Company: Bristol-Myers Squibb

Req Number: R1526909_EN

Updated: 2020-07-09 00:00:00.000 UTC

Location: Seattle,Washington

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

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